Validation of an Empiric Candidemia Treatment Algorithm

Reply to Bauer and Goff.

TO THE EDITOR—We read with interest the letter by Bauer and colleagues commenting on the need for cost-justification of new diagnostic tests in the field of infectious diseases [1], such as the recently US Food and Drug Administration–approved T2Candida panel for diagnosis of candidemia [2]. Indeed, the new alternatives for disease diagnosis [3] contribute to the exponential rise of healthcare ...

146Review of Empiric Echinocandin Therapy for Candidemia

146. Review of Empiric Echinocandin Therapy for Candidemia Cristina Amado, MD; Paul Blair, MD; Marc Siegel, MD, Medicine; John Keiser, MD; Infectious Diseases, George Washington University, Alexandria, VA; Internal Medicine, George Washington University, Washington, DC; Medical Faculty Associates/George Washington University Medical Center, Washington, DC; George Washington University Hospital,...

Risk Factors for Candidemia as Compared with Patients with Negative Blood Cultures Placed on Empiric Micafungin

Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation

INTRODUCTION Recent epidemiologic literature indicates that candidal species resistant to azoles are becoming more prevalent in the face of increasing incidence of hospitalizations with candidemia. Echinocandins, a new class of antifungal agents, are effective against resistant candidal species. As delaying appropriate antifungal coverage leads to increased mortality, we evaluated the cost-effe...

The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study

Hospital mortality rates are elevated in critically ill patients with bloodstream infections. Given that mortality may be even higher if appropriate treatment is delayed, we sought to determine the effect of inadequate initial empiric treatment on mortality in these patients. A retrospective cohort study was conducted across 13 intensive care units in Canada. We defined inadequate initial empir...